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Liquid being inserted into test tubes
Cellestia compound enters into clinical development

The Basel-based biotechnology company Cellestia has received approval for the first clinical trial on its compound CB-103. The clinical trial will be open to patients with solid tumours and haematological malignancies.


Cells react to external signals through NOTCH signalling pathways. When these signal pathways are damaged, NOTCH-dependant cancers such as leukaemia, lymphoma and solid tumours can develop. Cellestia developed CB-103 as a pan-NOTCH inhibitor to treat NOTCH-positive cancers by influencing these pathways.


The Basel-based company has now received full approval from the Spanish authorities for the first clinical trial Phase I-IIa in patients with solid tumours and haematological malignancies.


According to Cellestia’s Chief Medical Officer, Dirk Weber, they are currently no approved NOTCH-targeting agents on the market for this defined patient group, giving them a generally poor survival prognosis.


Michael Bauer, CEO of Cellestia, called reaching the clinical development stage a “major milestone” for the company.


Cellestia Biotech was founded in 2014 as a spin-off from the École polytechnique fédérale de Lausanne (EPFL). It specialises in development agents that target NOTCH signalling pathways. CB-103 is its most advanced programme to date.


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